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Related Concept Videos

Exocytosis00:50

Exocytosis

10.4K
Exocytosis is a process that releases molecules outside the cell. Like other bulk transport mechanisms, exocytosis requires energy.
Exocytosis is the opposite of endocytosis, which brings molecules inside the cell. Sometimes, the released materials are signaling molecules. For example, neurons typically use exocytosis to release neurotransmitters. Cells also use exocytosis to insert proteins such as ion channels into their cell membranes, secrete proteins for use in the extracellular matrix, or...
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Exocytosis00:51

Exocytosis

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Exocytosis is used to release material from cells. Like other bulk transport mechanisms, exocytosis requires energy.
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Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis01:18

Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

4.6K
Vesicular transport is a cellular process that encompasses the engulfment of particles or dissolved substances by cells. It involves endocytosis, transcytosis, and exocytosis.
Endocytosis is a cellular mechanism that involves the inward folding of the cell membrane to create vesicles that capture and transport large drug molecules. This process comprises two distinct methods: pinocytosis (often referred to as "cell drinking") and phagocytosis (often referred to as "cell...
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Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

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Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
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Protein Translocation Machinery on the ER Membrane01:28

Protein Translocation Machinery on the ER Membrane

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The translocon complex situated on the ER membrane is the main gateway for the protein secretory pathway. It facilitates the transport of nascent peptides into the ER lumen and their insertion into the ER membrane.
Sec61 protein conducting channel
In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the...
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Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

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Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
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Related Experiment Video

Updated: Apr 6, 2026

Automated Detection and Analysis of Exocytosis
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Automated Detection and Analysis of Exocytosis

Published on: September 11, 2021

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The Exocyst at a Glance.

Bin Wu1, Wei Guo2

  • 1Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Journal of Cell Science
|August 5, 2015
PubMed
Summary
This summary is machine-generated.

The exocyst complex, crucial for vesicle tethering, controls key cell processes like migration and tumor invasion. This review details its organization, function, and regulation for diverse cellular roles.

Keywords:
ExocystMembrane fusionRabRalRhoVesicle tether

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Area of Science:

  • Cell Biology
  • Molecular Biology

Background:

  • The exocyst is an octameric protein complex essential for tethering secretory vesicles to the plasma membrane.
  • This process precedes SNARE-mediated fusion, a critical step in exocytosis.

Purpose of the Study:

  • To summarize recent findings on the exocyst complex's molecular organization, function, and regulation.
  • To provide rationales for the exocyst's involvement in diverse cellular processes.

Main Methods:

  • Literature review of recent works on the exocyst complex.
  • Synthesis of information on molecular organization, function, and regulation.

Main Results:

  • The exocyst complex plays a vital role in spatial and temporal control of exocytosis.
  • Exocytosis regulated by the exocyst is crucial for morphogenesis, cell cycle progression, primary ciliogenesis, cell migration, and tumor invasion.

Conclusions:

  • The exocyst complex's diverse roles stem from its intricate molecular organization, function, and regulation.
  • Understanding the exocyst is key to comprehending fundamental cellular processes and diseases like cancer.