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Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
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Toward bioactive yet antibacterial surfaces.

I V Sukhorukova1, A N Sheveyko1, Ph V Kiryukhantsev-Korneev1

  • 1National University of Science and Technology "MISIS", Leninsky prospect 4, Moscow 119049, Russia.

Colloids and Surfaces. B, Biointerfaces
|August 10, 2015
PubMed
Summary
This summary is machine-generated.

Optimizing silver (Ag) concentration and nanoparticle state in TiCaPCON films creates antibacterial surfaces that are also biocompatible and bioactive for bone regeneration. These silver-doped nanocomposite films effectively kill bacteria while supporting osteoblast cell growth.

Keywords:
Antibacterial activityBioactivityMulticomponent filmsSilverSputtering

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Surface Chemistry
  • Cell Biology

Background:

  • Developing antibacterial, biocompatible, and bioactive surfaces remains a significant challenge in biomedical engineering.
  • Existing materials often fail to balance potent antimicrobial properties with favorable cellular interactions.
  • Silver (Ag) is a promising element for antimicrobial applications, but its optimal integration into composite materials needs further investigation.

Purpose of the Study:

  • To determine the ideal Ag concentration and agglomeration state within bioactive TiCaPCON nanocomposite films.
  • To achieve strong bactericidal effects without compromising material biocompatibility and bioactivity.
  • To investigate the synergistic effects of Ag nanoparticles and Ag+ ions on bacterial inhibition and osteoblast cell behavior.

Main Methods:

  • Fabrication of TiCaPCON films using magnetron sputtering with subsequent Ag+ ion implantation or co-sputtering with Ag.
  • Surface characterization including morphology, chemical composition, roughness, and wettability analysis.
  • Evaluation of Ag+ ion release, antibacterial/antifungal activity against Escherichia coli and Neurospora crassa, and osteoblast (MC3T3-E1) cell response (adhesion, proliferation, differentiation).

Main Results:

  • Optimized Ag content and agglomeration in TiCaPCON films demonstrated high efficacy against E. coli.
  • The developed surfaces supported excellent osteoblastic cell adhesion, spreading, proliferation, and differentiation.
  • Characterization confirmed the influence of Ag+ ions and nanoparticles on both bacterial inhibition and cellular responses.

Conclusions:

  • Ag-doped TiCaPCON nanocomposite films offer a promising solution for creating multifunctional surfaces.
  • The study successfully established optimal conditions for Ag integration, balancing potent antibacterial activity with enhanced biocompatibility and bioactivity.
  • These findings suggest potential applications in orthopedic and dental implants where infection prevention and bone integration are crucial.