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Hypoxic Ventilatory Reactivity in Experimental Diabetes.
M Pokorski1, M Pozdzik, J Antosiewicz
1Laboratory of Electrophysiology, Clinical Research Center, Murayama Medical Center, 2-37-1 Gakuen, MusashiMurayama City, Tokyo, 208-0011, Japan, m_pokorski@hotmail.com.
Advances in Experimental Medicine and Biology
|August 26, 2015
Summary
Diabetes dampens the hypoxic ventilatory response by altering carotid bodies (CBs). This study found diabetic CBs show structural changes, impairing oxygen sensing and potentially worsening inflammation.
Area of Science:
- Physiology
- Endocrinology
- Respiratory Medicine
Background:
- Diabetes mellitus is associated with tissue hypoxia and chronic inflammation.
- The role of carotid bodies (CBs) in ventilatory control during diabetes is not well understood.
- Existing research on ventilatory control in diabetes presents sparse and conflicting findings.
Purpose of the Study:
- To investigate the functional and morphological changes in carotid bodies (CBs) of diabetic rats.
- To assess the impact of diabetes on the hypoxic ventilatory response (HVR).
- To explore the microvascular and ultrastructural alterations in diabetic CBs.
Main Methods:
- Diabetes was induced in Wistar rats using streptozotocin.
- Acute hypoxic ventilatory responses were measured using plethysmography.
- Carotid bodies underwent ultrastructural analysis via transmission electron microscopy.
- Microvascular changes were visualized using laser scanning confocal microscopy with endothelial cell markers.
Main Results:
- Diabetic rats exhibited a significantly dampened hypoxic ventilatory response.
- Ultrastructural examination revealed connective tissue proliferation and neovascularization in diabetic CBs.
- These morphological changes disrupted the interglomal structure and increased the oxygen diffusion path.
- Microvascular assessment confirmed significant angiopathy and induced microvessel growth within the CBs.
Conclusions:
- Diabetes-induced remodeling of the carotid body parenchyma impairs its function.
- Altered carotid body structure in diabetes may contribute to impaired ventilatory control.
- These changes could exacerbate chronic hypoxia and inflammation in the carotid bodies.
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