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Updated: Apr 4, 2026
A High-performance Compact Photoacoustic Tomography System for In Vivo Small-animal Brain Imaging
Published on: June 21, 2017
High speed intravascular photoacoustic imaging with fast optical parametric oscillator laser at 1.7 μm
Zhonglie Piao, Teng Ma1, Jiawen Li2
1Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, University of Southern California , Los Angeles, California 90089, USA.
Abstract:
Intravascular photoacoustic imaging at 1.7 μm spectral band has shown promising capabilities for lipid-rich vulnerable atherosclerotic plaque detection. In this work, we report a high speed catheter-based integrated intravascular photoacoustic/intravascular ultrasound (IVPA/IVUS) imaging system with a 500 Hz optical parametric oscillator laser at 1725 nm. A lipid-mimicking phantom and atherosclerotic rabbit abdominal aorta were imaged at 1 frame per second, which is two orders of magnitude faster than previously reported in IVPA imaging with the same wavelength. Clear photoacoustic signals by the absorption of lipid rich deposition demonstrated the ability of the system for high speed vulnerable atherosclerotic plaques detection.
