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Updated: Apr 3, 2026

09:06
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
511
MicroRNA detection based on analyte triggered nanoparticle localization on a tetrahedral DNA modified electrode
Peng Miao1, Yuguo Tang, Jian Yin
1CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P. R. China. miaopeng@sibet.ac.cn.
Abstract:
We have constructed an ultrasensitive method for microRNA detection based on analyte triggered nanoparticle localization and hybridization chain reaction dual amplification. The limit of detection is 2 aM. Furthermore, the applicability of this method for microRNA assay in real samples is demonstrated by the analysis of cell lysates.

