Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

4.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.6K
Telomeres and Telomerase02:41

Telomeres and Telomerase

8.1K
8.1K
Telomeres and Telomerase02:41

Telomeres and Telomerase

28.6K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
28.6K
Replication in Eukaryotes01:29

Replication in Eukaryotes

19.1K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
19.1K
Replication in Eukaryotes02:31

Replication in Eukaryotes

208.1K
Overview
208.1K
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

3.4K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and safety of stem cell therapy in type 1 diabetes: A systematic review and meta-analysis of randomised controlled trials.

The Indian journal of medical research·2026
Same author

KDIGO Life Cycle of Guideline Development Series Part 5: Guideline updates and a living model for the future.

Kidney international·2026
Same author

KDIGO Life Cycle of Guideline Development Series Part 6: Bridging the Gap between Guidelines and Clinical Practice: The KDIGO Approach to Global Implementation and Education in Nephrology.

Kidney international·2026
Same author

Virtual Reality to Improve Breastfeeding Outcomes: A Systematic Review and Meta-Analysis.

Nursing reports (Pavia, Italy)·2026
Same author

ZW4864-mediated inhibition of the β-catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer.

Molecular oncology·2026
Same author

Kidney Disease: Improving Global Outcomes (KDIGO) life cycle of guideline development series: part 2: from initiation to publication: the KDIGO guideline development process.

Kidney international·2026
Same journal

Future Challenges of Molecular Imaging in Oncology.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same journal

Clinical Applications of Theranostics.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same journal

Internal Radiation Therapy.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same journal

The Role of Molecular Imaging in Ion Beam Therapy.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same journal

Molecular Imaging in Photon Radiotherapy.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same journal

Advancements in Intraoperative Imaging for Enhanced Surgical Precision.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
See all related articles

Related Experiment Video

Updated: Apr 3, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

10.8K

Telomere Dysfunction, Chromosomal Instability and Cancer.

Jitendra Meena1, K Lenhard Rudolph2, Cagatay Günes3

  • 1Leibniz Institute for Age Research, Fritz Lipmann Institute e.V., 07745, Jena, Germany.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|September 18, 2015
PubMed
Summary
This summary is machine-generated.

Telomeres protect chromosome ends but shorten with cell division. This shortening can initiate cancer, while reactivated telomerase in tumors stabilizes chromosomes for immortal growth.

Keywords:
Genome stabilitySenescenceTelomerase

More Related Videos

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells
09:13

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells

Published on: January 17, 2019

7.9K
Chromosome Preparation From Cultured Cells
07:42

Chromosome Preparation From Cultured Cells

Published on: January 28, 2014

84.5K

Related Experiment Videos

Last Updated: Apr 3, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

10.8K
Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells
09:13

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells

Published on: January 17, 2019

7.9K
Chromosome Preparation From Cultured Cells
07:42

Chromosome Preparation From Cultured Cells

Published on: January 28, 2014

84.5K

Area of Science:

  • Genetics
  • Molecular Biology
  • Cancer Biology

Background:

  • Telomeres are protective caps on linear chromosomes, crucial for stability.
  • They consist of repetitive DNA sequences (TTAGGG)n bound by proteins.
  • Telomere shortening occurs in cells lacking telomerase activity, leading to loss of capping function.

Purpose of the Study:

  • To review the critical role of telomeres in maintaining chromosomal stability.
  • To explore the dual function of telomeres in the initiation and progression of cancer.
  • To summarize current understanding of telomere maintenance and its implications in carcinogenesis.

Main Methods:

  • Literature review of current research on telomeres.
  • Analysis of telomere dynamics in cellular division and cancer.
  • Synthesis of information on telomere binding proteins and telomerase activity.

Main Results:

  • Telomere shortening contributes to chromosomal instability and tumor initiation.
  • Reactivation of telomerase is essential for tumor cell chromosomal stabilization and immortalization.
  • Telomeres exhibit a complex, dual role throughout the carcinogenic process.

Conclusions:

  • Telomeres are vital for chromosomal integrity and cellular lifespan.
  • Dysregulation of telomere length and telomerase activity is a hallmark of cancer.
  • Understanding telomere biology offers insights into cancer development and potential therapeutic strategies.