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Updated: Apr 3, 2026
Differentiation, Maintenance, and Analysis of Human Retinal Pigment Epithelium Cells: A Disease-in-a-dish Model for BEST1 Mutations
Published on: August 24, 2018
Effect of hrWnt7a on Human Retinal Pigment Epithelial Cells In Vitro
A V Kuznetsova1, A M Kurinov2, E V Chentsova3
1N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia. avkuzn@list.ru.
Abstract:
Human recombinant protein Wnt7a (hrWnt7a) inhibits cell proliferative activity and triggers cell polarization. Although cell polarization process was maintained only over a short time, probably via microenvironmental stimuli, hrWnt7a is involved in the transformation of the retinal pigment epithelium. Analysis of Wnt signaling pathway and its regulation will help to understand the processes in retinal pigment epithelial cells under pathological conditions, which can be useful in developing new generation drugs.
