Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

1.1K
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
1.1K
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

2.1K
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to 'Does Size and Site Matter in Therapeutic Decompressive Craniectomy? A Laboratory-Based Experimental Study' [World Neurosurgery 95 (2016) 441-446].

World neurosurgery·2017
Same author

Does Size and Site Matter in Therapeutic Decompressive Craniectomy? A Laboratory-Based Experimental Study.

World neurosurgery·2016
Same author

ALA-induced fluorescence image guided surgery of meningiomas: A meta-analyses.

Photodiagnosis and photodynamic therapy·2016
Same author

Intraoperative Ultrasound-Guided Resection of Gliomas: A Meta-Analysis and Review of the Literature.

World neurosurgery·2016
Same author

Dual Orientation 16-MHz Single-Element Ultrasound Needle Transducers for Image-Guided Neurosurgical Intervention.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2015
Same author

Laser-induced autofluorescence spectroscopy: can it be of importance in detection of bladder lesions?

Photodiagnosis and photodynamic therapy·2015

Related Experiment Video

Updated: Apr 3, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

29.9K

Vagus Nerve Stimulation for Major Depressive Episodes.

Sam Eljamel1

  • 1Department of Neurosurgery, Centre for Neurosciences, The University of Dundee, Dundee, Scotland, UK.

Progress in Neurological Surgery
|September 23, 2015
PubMed
Summary

Vagus nerve stimulation (VNS) offers a novel, well-tolerated antidepressive therapy for major depressive episodes. It demonstrates effectiveness with sustained responses and high compliance, showing fewer adverse effects than traditional treatments.

More Related Videos

Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation
04:59

Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation

Published on: January 19, 2024

4.1K
Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation taVNS: Technique, Targeting, and Considerations
06:31

Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation taVNS: Technique, Targeting, and Considerations

Published on: January 7, 2019

42.3K

Related Experiment Videos

Last Updated: Apr 3, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

29.9K
Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation
04:59

Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation

Published on: January 19, 2024

4.1K
Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation taVNS: Technique, Targeting, and Considerations
06:31

Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation taVNS: Technique, Targeting, and Considerations

Published on: January 7, 2019

42.3K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Devices

Background:

  • Left vagus nerve stimulation is an emerging therapy for depression.
  • It targets brainstem pathways involved in mood regulation.
  • Evidence supports its tolerability and effectiveness in major depressive episodes (MDE).

Purpose of the Study:

  • To summarize the effectiveness and tolerability of vagus nerve stimulation (VNS) for major depressive episodes (MDE).
  • To highlight the advantages of VNS compared to existing antidepressant therapies.

Main Methods:

  • Review of prospective and long-term studies on VNS in MDE.
  • Analysis of symptomatic response, remission rates, sustained response, and treatment maintenance.
  • Evaluation of tolerability, adverse events, and patient compliance.

Main Results:

  • Symptomatic response rates range from 15-17% at 10 weeks to 22-37% at 12 months.
  • Remission rates reach 15-17% after 12 months, with sustained response in 13-27%.
  • High continuation rates (90-98%) and low adverse event discontinuations (3%) indicate good tolerability.

Conclusions:

  • Vagus nerve stimulation (VNS) is an effective and well-tolerated treatment for major depressive episodes.
  • VNS offers advantages over drug therapy and electroconvulsive therapy, including no systemic effects, no overdose toxicity, and high patient compliance.
  • It can be safely added to existing antidepressant drug regimens without interactions.