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Updated: Apr 3, 2026

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
Published on: March 24, 2018
Crystal structure of (R)-6-fluoro-2-[(S)-oxiran-2-yl]chroman
Yoann Rousselin1, Hugo Laureano2, Alexandre Clavel2
1Universite de Bourgogne, ICMUB-UMR6302, 9 avenue Alain Savary, 21000 Dijon, France.
Abstract:
The title compound, C11H11FO2, is a building block in the synthesis of the active pharmaceutical ingredient dl-nebivolol. The synthesis starting from the enanti-omerically pure (R)-6-fluoro-4-oxo-3,4-di-hydro-2H-chromene-2-carb-oxy-lic acid resulted in a mixture of two stereoisomers, namely (R)-6-fluoro-2-[(S)-oxiran-2-yl]chroman and (R)-6-fluoro-2-[(R)-oxiran-2-yl]chroman. The mixture was separated by column chromatography but only one stereoisomer crystallized. The X-ray structure analysis revealed that the solid consisted of the R,S isomer. A similar procedure was repeated for (S)-6-fluoro-4-oxo-3,4-di-hydro-2H-chromene-2-carb-oxy-lic acid and, in this case, the S,R isomer was produced as a crystalline solid. Thus, all four stereoisomers of the title epoxide were obtained and their absolute configuration was assigned. The crystal studied was refined as an inversion twin.
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