Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vertebral Column: Regions and Curvature01:16

Vertebral Column: Regions and Curvature

11.5K
The vertebral column or spine is a flexible column that supports the head, neck, and body and  allows for their movements. It also protects the spinal cord.
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form...
11.5K
Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

4.9K
The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
4.9K
Neurulation01:30

Neurulation

47.4K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
47.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Worse Preoperative Disability is Predictive of Improvement in Disability After Complex Adult Spinal Deformity Surgery.

Global spine journal·2022
Same author

Complications following surgical treatment of adolescent idiopathic scoliosis: a 10-year prospective follow-up study.

Spine deformity·2022
Same author

Clinically relevant biomechanical properties of three different fixation techniques of the upper instrumented vertebra in deformity surgery.

Spine deformity·2022
Same author

Alvimopan for the reduction of postoperative ileus after long posterior spinal fusion: placebo-controlled double-blind randomized trial.

Journal of neurosurgery. Spine·2022
Same author

Evaluation of coronal alignment from the skull using the novel orbital-coronal vertical axis line.

Journal of neurosurgery. Spine·2022
Same author

How Does Gravity Influence the Distribution of Lordosis in Patients With Sagittal Malalignment?

Global spine journal·2022
Same journal

Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Spinal Cord Deformities Associated with Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Radiation Therapy for Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Treatment Strategies of Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Vascular Lesions of the Spinal Cord: Arteriovenous and Cavernous Malformations.

Neurosurgery clinics of North America·2026
Same journal

Hemangioblastomas of the Spinal Cord.

Neurosurgery clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Apr 3, 2026

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity
06:45

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Published on: September 16, 2022

3.0K

Spinal Deformity Associated with Chiari Malformation.

Michael P Kelly1, Tenner J Guillaume2, Lawrence G Lenke1

  • 1Department of Orthopedic Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Box 8233, Saint Louis, MO 63110, USA.

Neurosurgery Clinics of North America
|September 27, 2015
PubMed
Summary
This summary is machine-generated.

Chiari malformation can cause spinal deformities like scoliosis, even without syringomyelia. Hindbrain decompression may resolve deformities in young patients, while severe cases may require spinal fusion.

Keywords:
Chiari malformationEarly onsetScoliosisSyringomyeliaSyrinx

More Related Videos

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review
04:33

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Published on: November 8, 2024

1.0K
Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

1.6K

Related Experiment Videos

Last Updated: Apr 3, 2026

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity
06:45

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Published on: September 16, 2022

3.0K
Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review
04:33

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Published on: November 8, 2024

1.0K
Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

1.6K

Area of Science:

  • Neurology
  • Orthopedic Surgery
  • Developmental Biology

Background:

  • Chiari malformation frequently leads to spinal deformities, but the underlying mechanisms are not fully understood.
  • Spinal deformities such as scoliosis can occur with or without syringomyelia in patients with Chiari malformation.
  • Current treatment strategies for Chiari-associated spinal deformities lack comprehensive understanding of the disease process.

Purpose of the Study:

  • To investigate the pathophysiology of Chiari-associated spinal deformities.
  • To evaluate the efficacy of hindbrain decompression and spinal fusion in managing these conditions.
  • To improve prognostication and treatment strategies for patients with Chiari malformation and spinal deformities.

Main Methods:

  • Review of clinical data for patients with Chiari malformation and associated spinal deformities.
  • Analysis of treatment outcomes based on patient age and severity of spinal curvature (Cobb measurement).
  • Correlation of syringomyelia presence with spinal deformity progression and treatment response.

Main Results:

  • Chiari-associated spinal deformities are common but poorly understood.
  • Hindbrain decompression can resolve spinal deformities in young patients (<10 years) with Cobb measurements <40°.
  • Spinal fusion is indicated for progressive deformities exceeding 50°.

Conclusions:

  • Further research into the pathophysiology of Chiari-associated spinal deformities is essential.
  • Timely intervention with hindbrain decompression may prevent the need for spinal fusion in select pediatric cases.
  • Improved understanding will enhance prognostication and optimize treatment for this patient population.