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Updated: Apr 1, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
Gene-Diet Interactions in Age-Related Macular Degeneration
Sheldon Rowan1,2, Allen Taylor3,4,5
1USDA-JM Human Nutrition Research Center on Aging (HNRCA), Tufts University, 02111, Boston, MA, USA. Sheldon.rowan@tufts.edu.
Abstract:
Age-related macular degeneration (AMD) is a prevalent blinding disease, accounting for roughly 50 % of blindness in developed nations. Very significant advances have been made in terms of discovering genetic susceptibilities to AMD as well as dietary risk factors. To date, nutritional supplementation is the only available treatment option for the dry form of the disease known to slow progression of AMD. Despite an excellent understanding of genes and nutrition in AMD, there is remarkably little known about gene-diet interactions that may identify efficacious approaches to treat individuals. This review will summarize our current understanding of gene-diet interactions in AMD with a focus on animal models and human epidemiological studies.
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