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Updated: Apr 1, 2026

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System
Published on: February 4, 2021
Pigment Epithelium-Derived Factor, a Protective Factor for Photoreceptors in Vivo
Federica Polato1, S Patricia Becerra2
1Section of Protein Structure and Function, Laboratory of Retinal Cell and Molecular Biology, NEI, National Institutes of Health, NIH-NEI BG.6. Room 134. 6 Center Drive MSC 0608, 20892-0608, Bethesda, MD, USA. polatof@mail.nih.gov.
Abstract:
Pigment epithelium-derived factor (PEDF) is a natural protein of the retina with demonstrable neurotrophic properties, found in the interphotoreceptor matrix in intimate contact with photoreceptors. This review summarizes the effects of PEDF on photoreceptors in several animal models of retinal degeneration.
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