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Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging.
Marta E Rogowska1, D Robert Iskander1
1Department of Biomedical Engineering, Wroclaw University of Technology, Wroclaw, Poland.
Plos One
|October 14, 2015
Summary
Age affects corneal biomechanics. Younger and older adults show subtle, yet detectable, differences in corneal deformation response to air-puff tonometry, particularly in the posterior corneal profile dynamics.
Area of Science:
- Ophthalmology
- Biomechanical Engineering
- Gerontology
Background:
- Corneal biomechanics are crucial for accurate intraocular pressure measurement.
- Age-related changes in ocular tissues may influence corneal response to tonometry.
- Understanding these changes is vital for interpreting tonometry results across different age groups.
Purpose of the Study:
- To investigate age-related alterations in the dynamic deformation of the cornea.
- To analyze how corneal response to air-puff applanation tonometry differs between younger and older healthy individuals.
Main Methods:
- Prospective study of 50 healthy subjects, divided into two age groups (≤28 and ≥50 years).
- Corneal deformation analysis using a Scheimpflug-based device to capture anterior and posterior corneal profiles.
- Modeling of corneal dynamics using Chebyshev polynomial functions and bilinear fits, with statistical comparison between age groups via Wilcoxon rank sum and ANOVA/Friedman tests.
Main Results:
- Statistically significant age-related differences were found in the dynamic response of the posterior corneal profile during the second applanation phase (P<0.05).
- Two-way ANOVA/Friedman tests confirmed significant changes between age groups in this phase (P=0.017).
Conclusions:
- Corneal biomechanical properties are demonstrably influenced by age.
- High-speed imaging reveals subtle but observable age-related differences in corneal deformation dynamics, particularly during the cornea's return to its original shape post-air pulse.
