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Role of Chlamydia in Multiple Sclerosis

M V Ivanova1, N I Kolkova2, E Yu Morgunova2

  • 1Center of Neurology, Moscow, Russia. fspsbl@gmail.com.

Bulletin of Experimental Biology and Medicine
|October 16, 2015
PubMed

Insights

Chlamydia pneumoniae infection was more frequent in multiple sclerosis patients than controls, but its presence did not correlate with disease severity. Further research is needed to clarify the role of C. pneumoniae in multiple sclerosis pathogenesis.

Area of Science:

  • Neuroimmunology
  • Infectious Diseases
  • Microbiology

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.
  • The potential role of infectious agents, such as Chlamydia species, in MS pathogenesis is under investigation.

Purpose of the Study:

  • To investigate the presence of Chlamydia pneumoniae and Chlamydia trachomatis in patients with multiple sclerosis.
  • To analyze correlations between Chlamydia species detection and clinical characteristics of MS.

Main Methods:

  • Serological, molecular biological, and culture methods were employed.
  • Detection was performed in sera and cerebrospinal fluid.
  • Patients with MS were compared to neurologically healthy reference groups.

Main Results:

  • Chlamydia pneumoniae was detected more frequently in biological fluids of MS patients compared to controls.
  • The overall incidence of C. pneumoniae in MS patients was low and did not correlate with clinical manifestations.
  • Chlamydia trachomatis incidence was similarly low in both MS patients and controls.

Conclusions:

  • A subset of multiple sclerosis patients may be infected with Chlamydia pneumoniae.
  • The etiological or pathogenetic significance of Chlamydia pneumoniae in multiple sclerosis remains uncertain and requires further investigation.
Keywords:
Chlamydiamultiple sclerosis

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