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Outcome of Multi-Cystic Dysplastic Kidneys in Children

Suleiman D Mashat1, Sherif M El-Desoky1, Jameela Abdulaziz Kari1

  • 1Department of Pediatrics, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Iranian Journal of Pediatrics
|October 24, 2015
PubMed

Insights

Multicystic dysplastic kidney (MCDK) is the most common childhood cystic renal disease, often diagnosed prenatally. Most MCDK cases show good renal function and can spontaneously resolve, indicating a favorable prognosis.

Area of Science:

  • Pediatric Nephrology
  • Renal Pathophysiology
  • Medical Genetics

Background:

  • Renal cystic diseases represent a significant etiology of chronic kidney disease (CKD) in pediatric populations.
  • Understanding the specific patterns and outcomes of these diseases is crucial for effective management.

Purpose of the Study:

  • To delineate the epidemiological patterns of various renal cystic diseases in children.
  • To assess the clinical outcomes and prognosis for children diagnosed with multicystic dysplastic kidney (MCDK).

Main Methods:

  • A retrospective analysis was conducted on pediatric patients diagnosed with cystic kidney diseases.
  • Data were collected from King Abdulaziz University hospital between 2006 and 2014.

Main Results:

  • The study identified 55 children with cystic kidney diseases, including 25 with MCDK and 22 with polycystic kidney diseases (PKD).
  • MCDK and simple renal cysts were associated with good renal function, whereas PKD and nephronophthisis led to renal impairment.
  • A significant proportion of MCDK cases (56%) showed spontaneous involution by a mean age of 2.6 years, with most diagnosed prenatally.

Conclusions:

  • Multicystic dysplastic kidney (MCDK) is the predominant form of cystic renal disease in children, frequently detected during prenatal screening.
  • MCDK demonstrates a generally good prognosis, with many cases exhibiting spontaneous resolution and preserved renal function.
Abstract

Keywords:
ChildrenCystic Kidney DiseaseMulticystic Dysplastic Kidneys

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