[DNA modification and carcinogenesis--early events caused by a heterocyclic aromatic amine, Glu-P-1]

Isolation, structure and activity of a mutagen, 2-amino-6-methyldipyrido [1, 2-a: 3', 2'-d] imidazole (Glu-P-1), were summarized. The metabolic activation, its specific reaction with DNA and biomimetic mutation of proto-ras oncogene were described.