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Application of Humanized Mice in Immunological Research
1Department of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Room L7-56, 7/F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong, China. wwtu@hku.hk.
Methods in Molecular Biology (Clifton, N.J.)
|November 5, 2015
Summary
Humanized mouse models, particularly those with reconstituted human immune systems, are accelerating biomedical research. These advanced models bridge basic science and clinical applications for diagnostics and therapeutics.
Area of Science:
- Biomedical Research
- Immunology
- Translational Science
Background:
- Humanized mouse models have advanced significantly over the past decade.
- These models are crucial for translating basic research findings into clinical applications.
- Focus is placed on models with a reconstituted human immune system.
Purpose of the Study:
- To provide an overview of humanized mouse model history and progress.
- To review advancements in humanized immune system mice.
- To discuss applications in human immune system development and disease pathogenesis.
Main Methods:
- Review of diverse humanized mouse models.
- Focus on models with reconstituted human immune systems.
- Intensive review of advancements and applications.
Main Results:
- Humanized mouse models accelerate the translation of research to clinical strategies.
- These models are vital for studying human immune system development.
- Applications include understanding the pathogenesis of immune-related diseases.
Conclusions:
- Humanized mouse models are indispensable tools in biomedical research.
- They serve as a critical bridge between laboratory research and clinical trials.
- Future developments will continue to enhance their role in medicine.
