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Published on: February 4, 2021
Platelet-to-Lymphocyte Ratio May Predict the Severity of Calcific Aortic Stenosis
Serkan Akdag1, Aytac Akyol1, Muntecep Asker1
1Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
Insights
The platelet-to-lymphocyte ratio (PLR) is elevated in patients with calcific aortic stenosis (AS). Higher PLR levels correlate with increased AS severity, indicating its potential as an inflammatory marker.
Area of Science:
- Cardiology
- Inflammation markers
Background:
- Platelet-to-lymphocyte ratio (PLR) is an emerging inflammatory indicator linked to adverse cardiovascular events.
- Calcific aortic stenosis (AS) is a significant cardiovascular condition where inflammation plays a role.
Purpose of the Study:
- To investigate the relationship between PLR and the severity of calcific AS.
- To determine if PLR can serve as a marker for AS progression.
Main Methods:
- Retrospective study of 86 consecutive patients with calcific AS.
- Patients were categorized into mild-to-moderate AS and severe AS groups based on transaortic mean pressure gradient.
- PLR was calculated from complete blood count (CBC) data.
Main Results:
- PLR was significantly higher in both mild-to-moderate and severe AS groups compared to controls.
- PLR was significantly higher in the severe AS group compared to the mild-to-moderate AS group.
- A significant positive correlation was observed between PLR and transaortic mean pressure gradient in AS patients (r=0.421, p<0.001).
Conclusions:
- Increased PLR is associated with the severity of calcific AS.
- PLR may serve as a valuable inflammatory biomarker for assessing AS severity.
Background:
Platelet-to-lymphocyte ratio (PLR) is an emerging inflammatory indicator which is closely associated with adverse cardiovascular events. Therefore, we aimed to investigate the relationship between PLR and the severity of calcific aortic stenosis (AS).
Material And Methods:
The study was designed as a retrospective study. A total of 86 consecutive patients with calcific AS were divided into two groups as mild-to-moderate AS and severe AS according to the transaortic mean pressure gradient. PLR levels were calculated from the complete blood count (CBC).
Results:
Platelet to lymphocyte ratio was significantly higher in severe and mild-to-moderate AS groups when compared to the control subjects (151±31.2, p<0.001, 138±28.8 vs. 126±26.5, p=0.008, respectively). In the subgroup analysis of AS patients, PLR was found to be higher in the severe AS group compared to mild-to-moderate group (p<0.001). A significant correlation was found between PLR and transaortic mean pressure gradient in patients with AS (r=0.421, p<0.001).
Conclusions:
Our study results demonstrated that increased PLR correlates with the severity of calcific AS.
