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Current advances and future perspectives in extrusion-based bioprinting
Ibrahim T Ozbolat1, Monika Hospodiuk1
1Engineering Science and Mechanics Department, The Pennsylvania State University, University Park, PA, 16802, USA; The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
Biomaterials
|November 13, 2015
Summary
Extrusion-based bioprinting (EBB) offers versatile biofabrication for research and clinical use. Overcoming challenges in resolution, organ fabrication, and bioink development is key for its advancement in tissue engineering.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Tissue Engineering
Background:
- Extrusion-based bioprinting (EBB) has advanced significantly, enabling versatile fabrication of cells, tissues, and organ modules.
- Applications span basic research, pharmaceutics, and clinical settings, utilizing diverse bioinks like hydrogels and decellularized matrices.
Purpose of the Study:
- To provide a comprehensive review of current advancements in extrusion-based bioprinting technology.
- To identify and discuss the limitations and future directions for EBB in tissue engineering and regenerative medicine.
Main Methods:
- Review of current literature and advancements in extrusion-based bioprinting.
- Analysis of challenges including resolution, organ fabrication, bioink development, and regulatory hurdles.
Main Results:
- EBB demonstrates high versatility in printing various biologics and bioinks.
- Key challenges include achieving high resolution, enabling organ-scale fabrication, and developing advanced bioinks for biomimetic microenvironments.
Conclusions:
- EBB holds significant promise for tissue engineering and regenerative medicine.
- Addressing current limitations is crucial for translating EBB technology from the lab to clinical products.
