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Related Experiment Videos

Alterations in digestive function caused by pancreatic disease.

J E Doty1, A S Fink, J H Meyer

  • 1Department of Surgery, UCLA School of Medicine.

The Surgical Clinics of North America
|June 1, 1989
PubMed
Summary

Pancreatic exocrine insufficiency, a condition affecting fat absorption, is best managed with oral pancreatic enzymes and H2 blockers. Surgical intervention is cautioned against due to potential complications like steatorrhea.

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Area of Science:

  • Gastroenterology
  • Digestive Physiology

Background:

  • Pancreatic exocrine secretion is regulated by complex neurohormonal reflexes.
  • The pancreas produces a significant surplus of enzymes, as significant impairment of fat absorption occurs only when enzyme output drops below 10% of normal.

Purpose of the Study:

  • To review the management of pancreatic exocrine insufficiency.
  • To evaluate the efficacy of surgical and non-surgical interventions for pancreatic exocrine insufficiency.

Main Methods:

  • Literature review of studies on pancreatic exocrine function and insufficiency management.
  • Analysis of the impact of surgical resection versus oral enzyme replacement therapy.

Main Results:

  • Surgical therapy does not improve pancreatic exocrine insufficiency and can precipitate steatorrhea.

Related Experiment Videos

  • Oral pancreatic enzymes are effective in managing diarrhea associated with steatorrhea.
  • Adjunctive H2 blockers or acid-resistant enzyme formulations may be necessary to prevent enzyme inactivation.

    • Conclusions:

    • Pancreatic resection should be approached cautiously in patients without evident exocrine insufficiency.
    • Effective management requires a multimodal approach including diet, behavior, and long-term follow-up.
    • Malnutrition remains a significant cause of mortality in chronic pancreatitis patients despite treatment efforts.