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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

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Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
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Staphylococcal Skin Infections01:29

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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Mechanism of Antibiotic Resistance in MRSA01:25

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Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Updated: Mar 29, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Community-Acquired Methicillin Resistant Staphylococcus aureus Bacteremia: Case Series.

J K E Veni1, G Bhat1, S M Shalini1

  • 1Department of Microbiology Kasturba Medical College (Manipal University) Mangalore, India.

Kathmandu University Medical Journal (KUMJ)
|December 2, 2015
PubMed
Summary

Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) can cause severe invasive infections beyond skin issues. This study details four bacteremia cases, highlighting risk factors and outcomes for this serious pathogen.

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Clinical Medicine

Background:

  • Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen.
  • While typically causing skin and soft tissue infections, MRSA is increasingly linked to invasive diseases.
  • Understanding MRSA's role in invasive infections is crucial for public health.

Observation:

  • Four cases of bacteremia caused by community-acquired MRSA were identified.
  • Patients presented with invasive MRSA infections, not solely skin and soft tissue infections.
  • Specific risk factors for developing MRSA bacteremia were noted.

Findings:

  • Community-acquired MRSA bacteremia can occur in diverse patient populations.
  • Identified risk factors included immunodeficiency and pre-existing skin and soft tissue infections.
  • Outcomes varied among the presented cases, underscoring the need for prompt diagnosis and treatment.

Implications:

  • This case series expands the understanding of MRSA bacteremia presentation and risk factors.
  • Highlights the importance of considering MRSA in invasive infections, even in the community setting.
  • Informs clinical practice regarding the management and prevention of severe MRSA infections.