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Animal Models in Studying Cerebral Arteriovenous Malformation
Ming Xu1, Hongzhi Xu2, Zhiyong Qin2
1Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Biomed Research International
|December 10, 2015
Summary
Animal models are crucial for understanding brain arteriovenous malformation (AVM) and its associated hemorrhagic stroke. This review summarizes existing AVM models to advance research and therapeutic development.
Area of Science:
- Neurology
- Vascular Biology
- Translational Medicine
Background:
- Brain arteriovenous malformation (AVM) is a significant cause of hemorrhagic stroke.
- The underlying causes and optimal treatments for AVM remain poorly understood and debated.
- Animal models offer a vital platform for investigating AVM pathogenesis and evaluating potential therapies.
Purpose of the Study:
- To review and summarize existing animal models of brain arteriovenous malformation (AVM).
- To consolidate current knowledge on AVM pathogenesis, growth, and rupture mechanisms.
- To highlight the utility of AVM animal models in preclinical research and therapeutic development.
Main Methods:
- A comprehensive literature search was conducted on PubMed up to December 31, 2014.
- Search terms included "arteriovenous malformation," limited to animal studies and English language publications.
- Reviewed articles described the creation, application, and findings of AVM animal models.
Main Results:
- Over 100 relevant articles were identified and reviewed.
- Eight distinct types of original AVM animal models were summarized.
- Details on model creation, procedures, applications, and research outcomes were presented.
Conclusions:
- Animal models are indispensable tools for studying the development, progression, and rupture of brain AVMs.
- These models facilitate the development and testing of novel treatment strategies for AVM.
- Further development of improved AVM animal models is anticipated to enhance research efficacy.
