The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

Area of Science:

• Pharmacology
• Drug Discovery
• Biomedical Sciences

Background:

• The Concise Guide to Pharmacology is a key resource for understanding human drug targets.
• It is produced in conjunction with NC-IUPHAR, providing official IUPHAR classification and nomenclature.
• This guide consolidates information from IUPHAR-DB and GRAC.

Purpose of the Study:

• To provide concise overviews of over 1750 human drug targets and their pharmacology.
• To link to an open-access knowledgebase (www.guidetopharmacology.org) for detailed target and ligand properties.
• To offer nomenclature guidance and summary information on pharmacological tools, references, and further reading.

Main Methods:

• Compilation of data on human drug targets and their pharmacology.
• Categorization of targets into eight major groups, including G protein-coupled receptors.
• Presentation of information in a landscape format for easy comparison.

Main Results:

• Overviews of 1750+ human drug targets with pharmacology.
• Links to a comprehensive open-access knowledgebase for deeper insights.
• Summary of pharmacological tools, references, and suggestions for further reading.

Conclusions:

• The Concise Guide serves as a condensed, citable record of drug target information.
• It provides a valuable, up-to-date resource for researchers in pharmacology and drug discovery.
• The guide facilitates comparison of related targets and aids in identifying pharmacological tools.