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Frequency and Mortality Associated with Hyperglycemia in Critically Ill Children

Sabeen Abid Khan1, Mohsina Noor Ibrahim2, Anwar-ul-Haq1

  • 1Department of Paediatrics, The Aga Khan University Hospital, Karachi.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|December 23, 2015
PubMed

Insights

Hyperglycemia is common in critically ill children and linked to higher mortality. Maintaining normal blood sugar levels in pediatric intensive care units (PICU) improves outcomes.

Area of Science:

  • Pediatric Critical Care Medicine
  • Endocrinology
  • Clinical Research

Background:

  • Hyperglycemia in critically ill children is a significant concern.
  • Understanding its prevalence and impact on mortality is crucial for improving patient outcomes.

Purpose of the Study:

  • To determine the frequency of hyperglycemia in critically ill children admitted to a pediatric intensive care unit (PICU).
  • To compare the mortality rates between hyperglycemic and normoglycemic critically ill children.

Main Methods:

  • A cross-sectional study was conducted in the PICU of the National Institute of Child Health (NICH), Karachi.
  • 150 critically ill children were enrolled; hyperglycemia was defined as fasting blood sugar >126 mg/dl within 48 hours of admission.
  • Patients were followed for 10 days to assess mortality associated with hyperglycemia.

Main Results:

  • Hyperglycemia was prevalent in 54.7% (82/150) of the critically ill children.
  • The overall mortality rate was 48.7% (73/150).
  • Mortality was significantly higher in the hyperglycemic group (57.3%) compared to the normoglycemic group (p=0.019).

Conclusions:

  • Stress-induced hyperglycemia in critically ill children is a marker of poor prognosis and high mortality.
  • Achieving normoglycemia is associated with better outcomes, including reduced mortality and shorter hospital stays.
Abstract

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