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Macrostomia: A Practical Guide for Plastic and Reconstructive Surgeons.
Edward M Kobraei1, Ashley K Lentz, Kyle R Eberlin
1*Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA †Division of Plastic and Reconstructive Surgery, University of Florida Health Science Center, University of Florida College of Medicine, Gainesville, FL ‡Department of Plastic Surgery, Guy's & St. Thomas' Hospital, London, United Kingdom §Global Smile Foundation, Tufts University School of Medicine, Harvard Medical School, and Clinical Instructor of Otolaryngology, Boston University School of Medicine. Boston, MA.
This guide reviews macrostomia, a rare congenital anomaly, detailing its diagnosis, embryology, and surgical repair. It presents an effective reconstruction method with 5-year results for plastic surgeons.
Area of Science:
- Plastic Surgery
- Congenital Anomalies
- Surgical Techniques
Background:
- Macrostomia is a rare congenital anomaly with unclear origins and varied presentations.
- Accurate diagnosis and management are crucial for plastic surgeons.
- Understanding the condition's anatomy, embryology, and clinical features is essential.
Observation:
- Phenotypic variability exists in macrostomia cases.
- Historical surgical repair methods provide context for modern techniques.
- A review of 5-year outcomes for a specific repair method is included.
Findings:
- An effective method for macrostomia repair is presented.
- The manuscript reviews the historical evolution of surgical repair techniques.
- Five-year results of the presented effective method are analyzed.
Implications:
- This guide aims to equip plastic and reconstructive surgeons with knowledge for safe and effective macrostomia repair.
- The goal is to achieve functional and aesthetic outcomes in macrostomia reconstruction.
- It serves as a reference for managing this complex congenital condition.

