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Epigenetics in Personalized Management of Lung Cancer

Aamir Ahmad1

  • 1Karmanos Cancer Institute, Wayne State University, Detroit, MI, 48201, USA. ahmada@karmanos.org.

Advances in Experimental Medicine and Biology
|December 26, 2015
PubMed

Insights

Epigenetic regulation, including methylation and acetylation, is crucial for cancer development. Targeting these epigenetic events offers potential for personalized lung cancer therapies, though further research is needed.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Cancer research focus shifted from genetic to epigenetic factors.
  • Epigenetic modifications like methylation and acetylation influence oncogene expression and tumor suppressor activity.
  • Approved epigenetic drugs exist but not yet for lung cancer.

Purpose of the Study:

  • Review the role of epigenetic events in human cancers.
  • Discuss the potential of targeting epigenetic modifications for personalized lung cancer therapy.
  • Highlight current progress and future directions in this field.

Main Methods:

  • Literature review of epigenetic regulation in cancer.
  • Analysis of methylation and acetylation in oncogene and tumor suppressor function.
  • Examination of current and potential epigenetic therapies for lung cancer.

Main Results:

  • Epigenetic events significantly impact cancer progression.
  • Targeting epigenetic modifications is a promising avenue for personalized cancer treatment.
  • Progress in applying epigenetic therapies to lung cancer is ongoing but requires further development.

Conclusions:

  • Epigenetic regulation plays a critical role in cancer, distinct from genetic factors.
  • Personalized epigenetic therapies hold significant promise for lung cancer treatment.
  • Continued research is essential to fully realize the therapeutic potential of targeting epigenetic events in lung cancer.
Keywords:
AcetylationDNMTEpigeneticsHDAC inhibitorsMethylation

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