Related Experiment Video
Updated: Mar 28, 2026

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry
Published on: January 19, 2020
[THE ROLE OF NITRIC OXIDE AND BLOOD RHEOLOGICAL PROPERTIES IN THE MAINTENANCE OF A TEMPERATURE HOMEOSTASIS IN THE
N Jojua1, N Gongadze1, N Mitagvariya1
1Tbilisi State Medical University, I. Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia.
Abstract:
The problem of temperature regulation in the brain tissue in conditions of whole body hyperthermia was investigated in experiments on white rats. The received results revealed that the brain is provided with a highly efficient system for temperature autoregulation against the changes in environmental temperature. According to our data the upper limit of this autoregulation (for rats, at least) is about the 450C of environmental temperature. The important role in functioning of this autoregulatory system belongs to Nitric Oxide. It is revealed also that the increase in the index of red cells aggregability may significantly hinder (among other things) maintaining of the temperature homeostasis in the brain.
More Related Videos
06:24Paired Cisterna Magna Nanoinjection and Laser Speckle Contrast Imaging Assay to Study Cerebral Blood Flow Regulation In Vivo
Published on: July 8, 2025
08:21Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
Published on: July 21, 2023
Related Concept Videos
Autoregulation of Blood Flow
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
Nitric Oxide Signaling Pathway
Neural Regulation of Blood Pressure
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Homeostatic Imbalances in Body Temperature
Requirements for Human Life
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
Regulation of the Cardiovascular System
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...