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Updated: Mar 27, 2026
07:50
Efficient Agroinfiltration of Plants for High-level Transient Expression of Recombinant Proteins
Published on: July 23, 2013
51.5K
Molecular pharming - VLPs made in plants
Johanna Marsian1, George P Lomonossoff1
1Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom.
Current Opinion in Biotechnology
|January 17, 2016
Summary
Plant-based expression provides a cost-effective method for producing therapeutics. This review covers plant expression techniques and advances in transiently expressed virus-like particles (VLPs) for vaccines.
Area of Science:
- Biotechnology
- Molecular Biology
- Vaccinology
Background:
- Plant-based expression systems offer a sustainable and scalable platform for biopharmaceutical production.
- Virus-like particles (VLPs) mimic viral structures, inducing strong immune responses without infection, making them promising vaccine candidates.
Purpose of the Study:
- To review current methods for plant-based therapeutic production.
- To highlight recent advancements in transient expression of plant-made virus-like particles (VLPs).
Main Methods:
- Review of literature on plant expression technologies.
- Analysis of transient expression systems for VLP production in plants.
Main Results:
- Plant expression is a safe, cost-effective, and flexible approach for producing therapeutics.
- Transient expression in plants enables rapid VLP manufacturing.
Conclusions:
- Plant-based VLP production is a viable and rapidly developing field for vaccine development.
- Further research into transient expression methods can accelerate the availability of plant-made vaccines.
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