Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations between maternal child maltreatment predict their child's health service use? Results from the I-CALM study.

Child abuse & neglect·2026
Same author

Evaluation of the UK's COVID-19 public health policy "Shielding: Results of a linked data matched cohort study.

Public health·2025
Same author

OSAIRIS: Lessons Learned From the Hospital-Based Implementation and Evaluation of an Open-Source Deep-Learning Model for Radiotherapy Image Segmentation.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

The accuracy of prehospital triage decisions in English trauma networks - a case-cohort study.

Scandinavian journal of trauma, resuscitation and emergency medicine·2024
Same author

Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff.

BMC emergency medicine·2024
Same author

Longitudinal data resource from the Wellbeing of Older People cohort of people aged >50 years in Uganda and South Africa from 2009 to 2019.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2023
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Mar 27, 2026

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

25.9K

Neurovascular Interactions in the Neurologically Compromised Neonatal Brain.

H Singh1,2, R Cooper3,4, C W Lee3,5

  • 1neoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK. harsimrat.singh@ucl.ac.uk.

Advances in Experimental Medicine and Biology
|January 20, 2016
PubMed
Summary
This summary is machine-generated.

Hypoxic ischaemic encephalopathy (HIE) in newborns can cause seizures and poor development. Simultaneous diffuse optical tomography (DOT) and electroencephalography (EEG) revealed key neurovascular changes during seizures in HIE neonates.

Keywords:
Burst suppressionDiffuse optical tomographyHypoxic–ischaemic encephalopathyNeonatal seizuresNeurovascular coupling

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.4K

Related Experiment Videos

Last Updated: Mar 27, 2026

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

25.9K
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.4K

Area of Science:

  • Neonatal neurology
  • Neuroscience
  • Biomedical engineering

Background:

  • Neurological brain injuries like hypoxic ischaemic encephalopathy (HIE) and seizures are linked to adverse developmental outcomes in neonates.
  • Limited understanding of the neurological and cerebrovascular mechanisms of seizures hinders diagnosis and treatment.
  • Diffuse optical tomography (DOT) offers insights into haemodynamic changes (deoxygenated/oxygenated hemoglobin) crucial for understanding seizures and neurovascular coupling.

Purpose of the Study:

  • To investigate the neurovascular processes underlying seizures in neonates with HIE.
  • To explore the utility of simultaneous electroencephalography (EEG) and DOT for studying neonatal seizures.
  • To analyze the temporal correlation between electrographic seizures and haemodynamic changes.

Main Methods:

  • Simultaneous recording of electroencephalography (EEG) and diffuse optical tomography (DOT) data.
  • Acquisition of DOT-EEG data from two neonates diagnosed with HIE.
  • Analysis of haemodynamic changes (de/oxygenated hemoglobin concentrations) in relation to electrographic seizure activity.

Main Results:

  • Distinct haemodynamic changes were observed using DOT.
  • These haemodynamic changes were temporally correlated with electrographic seizures detected by EEG.
  • The study successfully acquired mutually informative DOT-EEG data from HIE neonates.

Conclusions:

  • Simultaneous DOT-EEG is a valuable technique for studying neurovascular coupling in HIE neonates.
  • The findings provide insights into the haemodynamic changes associated with seizures in this population.
  • This approach can improve the understanding and potential management of seizures in neonatal HIE.