Abdominal aortic aneurysms--glycaemic status and mortality
Iren Drange Hjellestad1, Eirik Søfteland1, Roy Miodini Nilsen2
1Department of Medicine, Haukeland University Hospital, Jonas Lies vei 65, 5021, Bergen, Norway.
Journal of Diabetes and Its Complications
|January 23, 2016
Summary
Diabetes mellitus (DM) significantly increases mortality risk in abdominal aortic aneurysm (AAA) patients. Early HbA1c testing for AAA patients is crucial for identifying undiagnosed diabetes and improving outcomes.
Area of Science:
- Vascular Surgery
- Endocrinology
- Diabetology
Background:
- Abdominal aortic aneurysm (AAA) is a significant vascular condition.
- Glycaemic status is a critical factor in cardiovascular health and surgical outcomes.
- The interplay between diabetes mellitus (DM) and AAA outcomes requires further investigation.
Purpose of the Study:
- To evaluate the prevalence of DM and its association with mortality in patients with AAA.
- To assess glycaemic status using both oral glucose tolerance tests (OGTT) and HbA1c.
- To determine if glycaemic status predicts mortality in AAA patients.
Main Methods:
- A cohort of 66 patients with AAA undergoing elective surgery was studied.
- Glycaemic status was assessed via OGTT and HbA1c, with data available for 58 patients.
- Patients were classified as having DM, prediabetes, or normoglycaemia based on WHO and ADA criteria.
Main Results:
- The prevalence of newly diagnosed DM was 12% (OGTT) and 14% (HbA1c).
- All-cause mortality was 43% over a mean follow-up of 68 months.
- HbA1c was an independent predictor of mortality in the DM group (HR 6.35, p=0.01).
Conclusions:
- DM, particularly when defined by HbA1c ≥ 6.5%, is a significant determinant of mortality post-AAA surgery.
- A substantial proportion of AAA patients with DM were previously undiagnosed.
- Routine HbA1c screening is recommended for all AAA patients to identify DM and mitigate mortality risks.
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