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Updated: Mar 26, 2026

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
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Propofol-induced Inhibition of Catecholamine Release Is Reversed by Maintaining Calcium Influx

Liping Han1, Stephen Fuqua, Quanlin Li

  • 1From the Department of Anesthesiology (L.H., X.H.) and Department of Thoracic Surgery, Dalian Municipal Friendship Hospital (L.Z.), Dalian Medical University, Dalian, Liaoning, China; Department of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk, Virginia (S.F., G.L.); Department of Urology, the First Affiliated Hospital (Q.L.) and Department of Physiology (A.L.), Dalian Medical University, Dalian, Liaoning, China; Division of Fundamental Neurobiology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada (L.H., S.G., R.S., S.S.); and Department of Physiology, University of Toronto, Toronto, Ontario, Canada (S.S.).

Anesthesiology
|January 26, 2016
PubMed
Summary

Propofol, a common anesthetic, can lower blood pressure by affecting catecholamine release. This study found propofol actually enhances catecholamine release when calcium influx is present, offering new insights into preventing hypotension.

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