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Sclerostin in Obstructive Sleep Apnea
M Kosacka1, I Porębska2, A Brzecka2
1Department of Pulmonology and Lung Cancer, Wroclaw Medical University, 105 Grabiszynska St., 53-439, Wrocław, Poland. mokka113@hotmail.com.
Advances in Experimental Medicine and Biology
|January 29, 2016
Summary
Elevated sclerostin levels were observed in women with obstructive sleep apnea (OSA), correlating with OSA severity and cardiovascular issues. No significant differences were found in men, suggesting a sex-specific association.
Area of Science:
- Cardiovascular Research
- Sleep Medicine
- Endocrinology
Background:
- Sclerostin, a key regulator of bone metabolism, is implicated in vascular calcification and cardiovascular disorders.
- Obstructive sleep apnea (OSA) is a prevalent condition frequently linked to cardiovascular comorbidities.
Purpose of the Study:
- To investigate serum sclerostin levels in patients diagnosed with obstructive sleep apnea (OSA).
- To explore the relationship between sclerostin levels, OSA severity, and the presence of cardiovascular comorbidities, particularly examining potential sex differences.
Main Methods:
- Serum sclerostin was quantified using ELISA in 106 OSA patients (43 women) and 49 healthy controls.
- Patient data included age, BMI, apnea/hypopnea index (AHI), and cardiovascular comorbidity status.
- Statistical analyses were performed to compare sclerostin levels and assess correlations.
Main Results:
- Female OSA patients exhibited significantly higher sclerostin levels compared to female controls.
- Sclerostin levels in women with OSA positively correlated with AHI and desaturation index.
- In female OSA patients, sclerostin was elevated in those with cardiovascular comorbidities compared to those without.
- No significant differences in serum sclerostin were found between male OSA patients and male controls, nor was it associated with cardiovascular diseases in men.
Conclusions:
- Increased serum sclerostin is associated with OSA severity and cardiovascular sequelae specifically in female patients.
- The findings suggest a potential sex-specific role for sclerostin in the cardiovascular complications of OSA.
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