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Nanoparticle-blood interactions: the implications on solid tumour targeting.

James Lazarovits¹, Yih Yang Chen¹, Edward A Sykes¹

¹Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada. warren.chan@utoronto.ca and Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada.

Chemical Communications (Cambridge, England)

|February 2, 2016

Summary

This summary is machine-generated.

The protein corona formed by blood components hinders nanoparticle delivery to tumors. Understanding these interactions is key to improving nanoparticle cancer targeting and diagnostics.

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Published on: August 18, 2016

Area of Science:

Biomedical Engineering
Nanotechnology
Cancer Research

Background:

Nanoparticles are promising for cancer targeting and diagnostics.
Currently, less than 10% of systemically administered nanoparticles reach tumors.
Nanoparticle-blood interactions significantly impact their therapeutic efficacy.

Purpose of the Study:

To review how the protein corona affects nanoparticle targeting to solid tumors.
To explain current strategies for overcoming these targeting challenges.

Main Methods:

Exploration of nanoparticle-blood component interactions.
Analysis of protein corona formation and its effects.
Review of chemical strategies to mitigate protein adsorption.

Main Results:

Serum proteins adsorb onto nanoparticles, forming a protein corona.
The protein corona can block targeting ligands and promote macrophage uptake.
Increased nanoparticle size due to the corona hinders tumor penetration.

Conclusions:

Understanding nanoparticle-blood interactions is crucial for designing effective tumor-targeting nanoparticles.
Strategies to reduce protein adsorption can improve nanoparticle accumulation in tumors.
Optimizing nanoparticle physicochemical properties is essential for enhanced cancer therapy.