Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

Neurulation

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical Outcomes and Prognostication of CRTC1::TRIM11 Fusion Cutaneous Tumors.

The American journal of surgical pathology·2026

Same author

Genomic Landscape of Myoepithelial Carcinoma Tumors.

Oral diseases·2026

Same author

Pleomorphic rhabdomyosarcoma, outcomes of patients with advanced disease treated with systemic agents: Retrospective study from the global pushing ultra-rare sarcomas towards hope (PUSH) consortium.

European journal of cancer (Oxford, England : 1990)·2026

Same author

Novel FGL2::PDGFD and TGFBI::PDGFB Fusions Expand the Molecular Spectrum of Dermatofibrosarcoma Protuberans.

Genes, chromosomes & cancer·2026

Same author

EP300::VGLL3 fused rhabdomyoblastic tumor revisited: Is the label "rhabdomyosarcoma" justified?

Virchows Archiv : an international journal of pathology·2026

Same author

Pathologic Assessment of Retroperitoneal Sarcomas: A Position Paper By the Transatlantic Australasian Retroperitoneal Sarcoma Working Group.

The American journal of surgical pathology·2026

Same journal

Molecular Pathology in Contemporary Surgical Practice.

Surgical pathology clinics·2026

Same journal

Beyond Blood: Liquid biopsy assays for nonplasma body fluids.

Surgical pathology clinics·2026

Same journal

The Molecular Landscape of Ovarian Neoplasms: A Review.

Surgical pathology clinics·2026

Same journal

Clinically Relevant Molecular Pathology of Endometrial Cancer.

Surgical pathology clinics·2026

Same journal

Molecular Pathology of Genitourinary Tumors: Diagnostic, Prognostic, and Therapeutic Implications.

Surgical pathology clinics·2026

Same journal

Oncogenicity and Therapeutic Implications of Molecular Biomarkers in Colorectal Carcinoma.

Surgical pathology clinics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 26, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Primitive Round Cell Neoplasms.

¹Department of Histopathology, Royal Marsden Hospital, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK.

Surgical Pathology Clinics

|February 4, 2016

Summary

This summary is machine-generated.

Small round cell tumors are diverse soft tissue cancers often seen in children. Diagnosing these primitive round cell neoplasms requires advanced techniques like immunohistochemistry and molecular genetics.

More Related Videos

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

Related Experiment Videos

Last Updated: Mar 26, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

Area of Science:

Oncology
Pathology
Pediatric Oncology

Background:

Primitive round cell neoplasms, or small round cell tumors, are malignant soft tissue tumors characterized by monotonous undifferentiated cells and a high nuclear-cytoplasmic ratio.
These tumors frequently affect the pediatric population, though not exclusively.
The diverse morphology of small round cell tumors necessitates advanced diagnostic methods due to their presence across various tumor categories.

Purpose of the Study:

To highlight the diagnostic challenges posed by primitive round cell neoplasms of soft tissue.
To emphasize the importance of ancillary diagnostic techniques in identifying small round cell tumors.
To list the principal types of small round cell tumors encountered in clinical practice.

Main Methods:

Review of literature on primitive round cell neoplasms.
Analysis of diagnostic criteria for small round cell tumors.
Identification of key immunohistochemical and molecular genetic markers.

Main Results:

Small round cell tumors exhibit a characteristic morphology but are diagnostically challenging due to their diversity.
Immunohistochemistry and molecular genetics are crucial for accurate diagnosis.
Key tumors include Ewing sarcoma/primitive neuroectodermal tumor, desmoplastic small round cell tumor, alveolar rhabdomyosarcoma, poorly differentiated synovial sarcoma, neuroblastoma, and ganglioneuroblastoma.

Conclusions:

Accurate diagnosis of small round cell neoplasms relies heavily on ancillary techniques.
Early and precise diagnosis is critical for appropriate treatment and management of these pediatric and adult soft tissue tumors.
Further research into specific markers may improve diagnostic accuracy and therapeutic strategies.