Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

2.4K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.4K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.3K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.3K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

16.6K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
16.6K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

10.0K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
10.0K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

10.2K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myeloid/lymphoid neoplasm with FLT3 gene fusion: report of a case with a novel t(5;13)(q13;q12) SSBP2::FLT3 fusion.

Journal of hematopathology·2026
Same author

Challenges in Diagnosing High-grade B-cell Lymphoma, NOS: Poor Interobserver Agreement on Its Morphologic Definition-An LLMPP Study.

The American journal of surgical pathology·2026
Same author

Disruption of macrophage cell volume drives inflammatory responses and type I interferon signaling.

The Journal of cell biology·2026
Same author

RNA NGS testing provides additional diagnostic and prognostic information over metaphase karyotyping in routine clinical evaluation of acute leukemias and chronic myeloid neoplasms.

Human pathology·2026
Same author

Three practice updates in non-Hodgkin lymphoma for 2026.

Human pathology·2025
Same author

Gene expression profiling reveals 2 overarching types of ALCL with distinct targetable biology: an LLMPP study.

Blood·2025
Same journal

Molecular Pathology in Contemporary Surgical Practice.

Surgical pathology clinics·2026
Same journal

Beyond Blood: Liquid biopsy assays for nonplasma body fluids.

Surgical pathology clinics·2026
Same journal

The Molecular Landscape of Ovarian Neoplasms: A Review.

Surgical pathology clinics·2026
Same journal

Clinically Relevant Molecular Pathology of Endometrial Cancer.

Surgical pathology clinics·2026
Same journal

Molecular Pathology of Genitourinary Tumors: Diagnostic, Prognostic, and Therapeutic Implications.

Surgical pathology clinics·2026
Same journal

Oncogenicity and Therapeutic Implications of Molecular Biomarkers in Colorectal Carcinoma.

Surgical pathology clinics·2026
See all related articles

Related Experiment Video

Updated: Mar 26, 2026

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
12:58

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line

Published on: May 10, 2017

9.9K

Splenic B-Cell Lymphomas/Leukemias.

James R Cook1

  • 1Department of Clinical Pathology, Mail Stop L11, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Surgical Pathology Clinics
|February 4, 2016
PubMed
Summary
This summary is machine-generated.

Diagnosing splenic lymphoproliferative disorders is complex. Accurate classification of these lymphomas requires integrating morphology, clinical data, and genetic analysis for precise diagnosis.

Keywords:
Hairy cell leukemiaLymphomaSpleenSplenic marginal zone

More Related Videos

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model
08:00

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model

Published on: October 14, 2016

21.5K
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.9K

Related Experiment Videos

Last Updated: Mar 26, 2026

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
12:58

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line

Published on: May 10, 2017

9.9K
A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model
08:00

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model

Published on: October 14, 2016

21.5K
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.9K

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Lymphoproliferative disorders of the spleen present diagnostic challenges.
  • While some lymphomas primarily involve the spleen, others can secondarily affect it.

Purpose of the Study:

  • To discuss the diagnostic approach for splenic lymphoproliferative disorders.
  • To describe clinicopathologic features of lymphoid neoplasms presenting in the spleen.

Main Methods:

  • Integration of morphologic findings with clinical data.
  • Utilizing phenotypic, cytogenetic, and molecular genetic analyses.
  • Correlation with peripheral blood and bone marrow findings when necessary.

Main Results:

  • Splenic lymphomas like hairy cell leukemia and splenic marginal zone lymphoma characteristically present with splenic involvement.
  • Secondary splenic involvement can occur in any lymphoma type.
  • Precise classification depends on a multi-faceted diagnostic approach.

Conclusions:

  • A comprehensive diagnostic strategy is essential for accurate classification of splenic lymphoproliferative disorders.
  • Understanding the clinicopathologic features aids in diagnosing lymphoid neoplasms primarily presenting in the spleen.