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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging

Published on: March 20, 2013

Mapping immune cell infiltration using restricted diffusion MRI.

Fang-Cheng Yeh¹, Li Liu², T Kevin Hitchens^3,4

¹Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.

Magnetic Resonance in Medicine

|February 5, 2016

Summary

This summary is machine-generated.

Restricted diffusion imaging (RDI) quantifies cellularity using diffusion MRI. This novel method accurately measures cell density and detects immune cell infiltration, outperforming diffusion tensor imaging (DTI).

Keywords:

apparent diffusion coefficient (ADC)immune cell infiltration ischemia-reperfusion injury restricted diffusion restricted diffusion imaging (RDI)

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Area of Science:

Biomedical Imaging
Magnetic Resonance Imaging
Tissue Microstructure Analysis

Background:

Diffusion MRI offers noninvasive assessment of tissue microstructure.
Quantifying cellularity and immune cell infiltration remains a challenge in MRI.

Purpose of the Study:

To introduce Restricted Diffusion Imaging (RDI), a model-free diffusion MRI technique.
To quantify restricted diffusion and correlate it with cellularity.
To assess RDI's performance in phantom and animal studies.

Main Methods:

Derived an analytical relation between q-space signals and restricted spin density.
Validated RDI using a phantom study to assess cell density correlation.
Applied RDI to an animal model of myocardial ischemia-reperfusion injury to detect immune cell infiltration.

Main Results:

Phantom study demonstrated a strong correlation (R=0.998) between cell density and RDI-quantified restricted diffusion.
Animal study showed RDI high-value regions corresponded to macrophage infiltration areas.
RDI outperformed diffusion tensor imaging (DTI) in detecting macrophage infiltration and delineating inflammatory myocardium.

Conclusions:

Restricted Diffusion Imaging (RDI) effectively reveals cell density and immune cell infiltration.
RDI demonstrates superior specificity compared to DTI-derived diffusivity measurements.
RDI holds promise for assessing inflammatory conditions in tissues.