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Reinvestigation of the Branimycin Stereochemistry at Position 17-C
Ana Čikoš1, Nicolas Triballeau2, Paul A Hubbard3
1Fidelta, Ltd., Prilaz baruna Filipovića 29, 10000 Zagreb, Croatia.
Abstract:
A conformational study of branimycin was performed using single-crystal X-ray crystallography to characterize the solid-state form, while a combination of NMR spectroscopy and molecular modeling was employed to gain information about the solution structure. Comparison of the crystal structure with its solution counterpart showed no significant differences in conformation, confirming the relative rigidity of the tricyclic system. However, these experiments revealed that the formerly proposed stereochemistry of branimycin at 17-C should be revised.
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