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Updated: Mar 26, 2026

The Quantification of Injectability by Mechanical Testing
Published on: May 13, 2020
[Physicochemical incompatibilities of injectable drugs]
Christelle Hofmann1, Médéric Rouault1, Jérémy Cailleteau1
1Hôpital d'instruction des Armées Legouest, 27, avenue de Plantières, 57070 Metz, France.
Abstract:
The physicochemical interactions of injectable drugs administered through a Y-site injection port are little known phenomena, poorly documented but very frequent. Physicochemical incompatibility is defined as a chemical reaction between two injectable drugs which come into contact with each other. This chemical reaction may be visible on a macroscopic level or completely invisible. The risks of these interactions are not harmless, ranging from inefficacy to the toxicity of the newly-formed compounds.
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