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Doppler Optical Coherence Tomography of Retinal Circulation
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Quantitative contrast-enhanced optical coherence tomography.

Yonatan Winetraub, Elliott D SoRelle, Orly Liba

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    This summary is machine-generated.

    We developed a model to quantify signals from contrast agents in Optical Coherence Tomography (OCT). This tool accurately measures scattering particle concentration in various environments, advancing in vivo OCT imaging.

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    Area of Science:

    • Biomedical Optics
    • Medical Imaging
    • Nanotechnology

    Background:

    • Optical Coherence Tomography (OCT) is a non-invasive imaging technique.
    • Contrast agents enhance OCT signal but require accurate quantification.
    • Understanding signal behavior with varying concentrations is crucial for quantitative OCT.

    Purpose of the Study:

    • To develop and validate a model for quantifying signals from exogenous scattering agents in OCT.
    • To establish the relationship between OCT signal and particle concentration.
    • To enable accurate particle quantification in complex biological samples.

    Main Methods:

    • Developed a physics-based model predicting OCT signal trends based on scattering agent concentration.
    • Characterized signal dependence: linear, square root, and saturation at different concentrations.
    • Validated model predictions using gold nanorods (GNRs) across a wide concentration range (50 fM to 5 nM).

    Main Results:

    • Model accurately predicts concentration-dependent OCT signal trends.
    • Demonstrated linear relationship at low concentrations (<0.8 particles/voxel).
    • Observed square root dependence at higher concentrations due to interference and signal saturation from light attenuation.

    Conclusions:

    • The developed model accurately quantifies scattering agents in OCT.
    • Validated model performance in water, whole blood, and living animals.
    • Provides a valuable tool for quantitative contrast-enhanced in vivo OCT studies and coherence-based detection modalities.