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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.9K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Notch Signaling Pathway03:14

Notch Signaling Pathway

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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

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Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors

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The Notch meeting: an odyssey from structure to function.

Ajay Chitnis1, Laure Balle-Cuif2

  • 1Section on Neural Developmental Dynamics, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Building 6B, Room 3B-315, Bethesda, MD 20892, USA chitnisa@mail.nih.gov.

Development (Cambridge, England)
|February 18, 2016
PubMed
Summary

The Notch signaling pathway regulates cell interactions crucial for development and adult physiology. Understanding Notch function offers insights into diseases and regeneration strategies.

Keywords:
Molecular characterizationStructure-functionSystems biology

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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
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Area of Science:

  • Cellular and Molecular Biology
  • Developmental Biology
  • Signaling Pathways

Background:

  • The Notch signaling pathway is integral to numerous developmental processes.
  • Notch pathway dysfunction is implicated in multi-systemic diseases and cancer.
  • Notch signaling is vital for maintaining stem/progenitor cell populations, offering potential for regeneration.

Framework:

  • The Notch IX meeting convened scientists studying Notch signaling across diverse model systems and contexts.
  • Focus on molecular mechanisms governing Notch signaling and its developmental roles.
  • Discussions also encompassed the roles of Notch signaling in adult physiology.

Implementation:

  • Summarizes key presentations from the October 2015 Notch IX meeting in Athens, Greece.
  • Highlights research on the molecular underpinnings of Notch signaling.
  • Integrates findings from various model systems and research areas.

Implications:

  • Elucidates how Notch-mediated cell-cell interactions control development and physiology.
  • Advances understanding of Notch signaling in disease pathogenesis.
  • Opens new therapeutic avenues for regenerative medicine by targeting Notch pathways.