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Updated: Mar 24, 2026

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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The Hyperpolarization-Activated Cation Current Ih: The Missing Link Connecting Cannabinoids to Cognition.

Geoffrey A Vargish1, Chris J McBain1

  • 1Program in Developmental Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Neuron
|March 4, 2016
PubMed
Summary

Cannabinoids bidirectionally modulate neural circuit dynamics via CB1 receptors, impacting spatial working memory in mice. This research reveals a novel link between cannabinoid signaling and cognitive function.

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