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Skin changes in menopause.

J L Bolognia1, I M Braverman, M E Rousseau

  • 1Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.

Maturitas
|December 1, 1989
PubMed
Summary
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Estrogen deprivation in menopausal women may accelerate skin aging, particularly affecting elastic fibers. Hormone therapy showed no significant improvement in most skin symptoms over six months.

Area of Science:

  • Dermatology
  • Endocrinology
  • Aging Research

Background:

  • Menopausal women often experience skin changes, with photoaging potentially exacerbating symptoms like dryness and thinning.
  • Estrogen plays a role in maintaining skin structure and elasticity.

Purpose of the Study:

  • To investigate the relationship between estrogen deprivation and premature aging of dermal elastic fibers in menopausal women.
  • To assess the efficacy of transdermal 17 beta-estradiol in improving menopausal skin signs and symptoms.

Main Methods:

  • Examined skin signs and symptoms in 46 menopausal women before and after a 6-month estrogen replacement therapy (Estraderm).
  • Utilized light and electron microscopy to study elastic fibers in sun-protected skin of menopausal women, including those with premature menopause.

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Main Results:

  • Sun-exposed skin showed higher prevalence of pruritus, bruising, dryness, and thinning, indicating photoaging's impact.
  • No significant difference in most cutaneous signs/symptoms was observed between the estrogen treatment group and controls after 6 months, except for cutaneous flushing.
  • Prematurely menopausal women (ages 30-37) exhibited degenerative changes in dermal elastic fibers, resembling those typically seen in individuals 20 years older.

Conclusions:

  • Estrogen deprivation appears linked to premature aging of dermal elastic fibers.
  • Transdermal estrogen therapy demonstrated limited efficacy in improving overall menopausal skin symptoms within the study period.