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In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

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Therapy Effect: Impact on Bone Marrow Morphology.

K David Li¹, Mohamed E Salama¹

¹Hematopathology, Department of Pathology, University of Utah/ARUP Laboratories, 500 Chipeta Way, 115-G04, Salt Lake City, UT 84108, USA.

Surgical Pathology Clinics

|March 5, 2016

Summary

This summary is machine-generated.

This review details bone marrow changes after cancer treatments like chemotherapy and targeted therapies. Recognizing these post-treatment morphologic features is crucial to avoid misdiagnosing reactive patterns as cancer recurrence.

Keywords:

Bone marrow Hematologic malignancies Post-therapy and treatment effects

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Area of Science:

Hematology
Oncology
Pathology

Background:

Bone marrow biopsies are essential for diagnosing and monitoring hematologic malignancies.
Therapeutic interventions, including chemotherapy, growth factors, and targeted therapies, induce significant morphologic changes in the bone marrow.
Distinguishing treatment-related changes from residual or recurrent neoplastic processes is a critical diagnostic challenge.

Purpose of the Study:

To outline the common bone marrow morphologic alterations following chemotherapy, growth-stimulating agents, and targeted therapies.
To emphasize the importance of recognizing these reactive patterns to prevent misinterpretation as neoplastic processes.
To highlight the need for understanding drug-specific changes in the context of evolving targeted therapies.

Main Methods:

Review of literature on post-therapeutic bone marrow findings.
Analysis of morphologic changes induced by various treatment modalities.
Correlation of observed changes with specific therapeutic agents.

Main Results:

Chemotherapy, growth factors, and targeted therapies induce a spectrum of predictable bone marrow changes.
Common alterations include hypocellularity, dysplastic changes, and specific cellular responses.
Targeted therapies, such as tyrosine kinase inhibitors and immune modulators, present unique and drug-specific morphologic signatures.

Conclusions:

Awareness of post-therapeutic bone marrow morphologic features is vital for accurate interpretation of biopsies.
Differentiating reactive changes from neoplastic processes is essential for appropriate patient management.
Knowledge of drug-specific changes is increasingly important with the prevalent use of targeted therapies in hematologic malignancies.