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The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
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Updated: Mar 24, 2026

Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis
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Membrane traffic during axon development.

José Wojnacki1, Thierry Galli2

  • 1Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, CNRS UMR 7592, Membrane Traffic in Health & Disease, INSERM ERL U950, Paris, F-75013, France.

Developmental Neurobiology
|March 7, 2016
PubMed
Summary
This summary is machine-generated.

Membrane trafficking is crucial for neuronal development, regulating protein distribution and activation during axonal growth. Key proteins like SNAREs and Rabs play vital roles in this complex process.

Keywords:
RabSNAREaxonal plasticitymembrane trafficneuronal development

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Area of Science:

  • Neuroscience
  • Cell Biology

Background:

  • Neuronal development involves intricate neural circuit formation.
  • Gene expression, cytoskeletal dynamics, and membrane trafficking are critical for neuronal development.
  • Membrane trafficking delivers proteins and maintains polarity in developing neurons.

Purpose of the Study:

  • To review the roles of membrane trafficking in axonal development.
  • To focus on the involvement of SNAREs and Rabs in neuronal development.

Main Methods:

  • Literature review of studies on membrane trafficking in neuronal development.
  • Analysis of the roles of SNAREs and Rabs in axonal growth.

Main Results:

  • Membrane trafficking is essential for establishing specific and reproducible neural connections.
  • It actively regulates protein distribution and activation in neuronal subdomains and endosomes.
  • SNAREs and Rabs are key regulators of membrane trafficking during axonal development.

Conclusions:

  • Membrane trafficking plays a multifaceted and active role in axonal development.
  • Understanding the function of SNAREs and Rabs is critical for comprehending neuronal circuit formation.