[STUDY OF SAFETY OF PAROTITIS VACCINE].

Area of Science:

• Virology
• Immunology
• Pediatrics

Context:

• Monitoring vaccine safety is crucial for public health.
• The Leningrad-3 strain (L-3) mumps vaccine is widely used.
• Post-vaccinal complications require thorough investigation.

Purpose:

• To assess post-vaccinal complications in children immunized with the L-3 mumps vaccine.
• To evaluate the neurovirulence and reactogenicity of the L-3 mumps vaccine.
• To identify potential risk factors for adverse events.

Summary:

• A 3-year observational study involved 198,945 children vaccinated with 16 lots of L-3 mumps vaccine.
• Adverse events were monitored for 42 days post-vaccination, with serological and genetic analyses performed.
• Vaccine-associated aseptic meningitis was absent; vaccine-associated parotitis occurred in 0.06% of cases, with specific lots showing higher activity.

Impact:

• The L-3 mumps vaccine demonstrates low neurovirulence and reactogenicity.
• Specific vaccine lots were associated with a higher incidence of parotitis.
• A high immunization dose may contribute to post-vaccinal complications in some children.