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Isolated Orbital Aspergillosis in Immunocompetent Patients: A Multicenter Study
Ekta Aggarwal1, Kaustubh Mulay2, Vikas Menon3
1Drishti Eye Care and Vasan Eye Care Hospitals, Hyderabad, India.
American Journal of Ophthalmology
|March 15, 2016
Summary
Isolated orbital aspergillosis is a rare condition presenting as a progressive orbital mass. Early diagnosis and treatment are crucial for favorable outcomes, including resolution of proptosis and restored ocular motility.
Area of Science:
- Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Orbital aspergillosis is a fungal infection that can affect the eye socket.
- Isolated orbital aspergillosis, without systemic involvement, is uncommon.
Purpose of the Study:
- To describe the characteristics, imaging findings, and treatment results of isolated orbital aspergillosis.
- To highlight the importance of considering this rare condition in the differential diagnosis of orbital masses.
Main Methods:
- A multicenter, retrospective case series.
- Involved reviewing medical records and histopathology slides of 8 patients with isolated orbital aspergillosis.
Main Results:
- Gradual proptosis and eyelid swelling were common presenting symptoms.
- All patients experienced restricted ocular motility; treatment led to complete resolution of proptosis and restored motility.
- Aspergillus fumigatus was identified in one case; recurrence was noted in one patient.
Conclusions:
- Isolated orbital aspergillosis, though rare, should be suspected in patients with a gradually progressive orbital mass, particularly in individuals of Asian descent.
- Prompt recognition and management can significantly decrease the associated morbidity and mortality.
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