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Interleukin-10 as a Marker of Disease Progression in Dengue Hemorrhagic Fever
Ambreen Tauseef1, Naima Umar2, Sana Sabir3
1Department of Physiology, CMH, Lahore Medical and Dental College, Lahore.
Objective:
To evaluate the plasma interleukin-10 (IL-10) levels in patients suffering from dengue hemorrhagic fever between 4 to 7 days of onset of disease and 24 hours after the first sample, to find out the association of plasma IL-10 levels with the outcome.
Study Design:
Analytical study.
Place And Duration Of Study:
All major hospitals of Lahore, Pakistan, from August to November 2012.
Methodology:
Participants included 50 registered patients of dengue hemorrhagic fever (DHF) aged between 15 - 50 years. Plasma IL-10 concentrations were measured on above stated day. Outcome was described as recovery and shock. Platelet count and hematocrit percentages were also recorded. Statistical analyses were done using SPSS version 19. Ap-value ≤0.05 was considered significant.
Results:
Plasma IL-10 levels were found to be raised in DHF patients and were associated with fatal outcome (p=0.004). In recovered DHF patients, plasma IL-10 levels decreased after 24 hours (mean 26.54 ± 16.03 pg/ml) as compared to admission time (mean 74.39 ± 61.69 pg/ml) but in case of DHF patients suffering from shock, plasma IL-10 was found to be higher after 24 hours (mean 87.69 ± 7.77 pg/ml) as compared to levels at admission time (mean 42.56 ± 28.09 pg/ml). ROC curve analysis revealed a change (30 units pg/ml) of plasma IL-10 concentration, within 24 hours of admission, raised from the base line to be 105 times more critical for shock in DHF patients (100% sensitivity and 71.4% specificity, p < 0.001).
Conclusion:
Elevated plasma IL-10 is a potential predictor of disease severity and fatal outcome in DHF patients.
