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Pharmacogenetic Predictors of Response

Daniel L Hertz1, James M Rae2

  • 1Department of Clinical Pharmacy, University of Michigan College of Pharmacy, 48109, Ann Arbor, MI, USA.

Advances in Experimental Medicine and Biology
|March 19, 2016
PubMed
Summary

Pharmacogenetics uses germline genome variations to predict breast cancer treatment response. Key predictors include pharmacokinetics, cancer cell sensitivity, and immune cell activation, with examples like CYP2D6-tamoxifen and BRCA-PARP inhibitors.

Keywords:
BRCACYP2D6Cancer-cell sensitivityEffector-cell activationFCGRGermline polymorphismPharmacogeneticsPharmacokinetic predictors

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