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Pediatric Brain Tumors: Current Knowledge and Therapeutic Opportunities
John Glod1, Gilbert J Rahme, Harpreet Kaur
1Departments of †Genetics **Pediatrics ‡Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Hanover, NH *Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda §Division of Neuropathology and Sidney Kimmel Comprehensive Cancer Center ∥Division of Pediatric Oncology, Johns Hopkins School of Medicine, Bloomberg Children's Hospital, Baltimore, MD ¶The Brain Tumor Institute #Division of Hematology-Oncology, Children's National Medical Center, Washington, DC.
None:
Great progress has been made in many areas of pediatric oncology. However, tumors of the central nervous system (CNS) remain a significant challenge. A recent explosion of data has led to an opportunity to understand better the molecular basis of these diseases and is already providing a foundation for the pursuit of rationally chosen therapeutics targeting relevant molecular pathways. The molecular biology of pediatric brain tumors is shifting from a singular focus on basic scientific discovery to a platform upon which insights are being translated into therapies.
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