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Multidisciplinary management of nonfunctional neuroendocrine tumor of the pancreas

Ian W Folkert1, Paul Hernandez1, Robert E Roses1

  • 1Ian W Folkert, Paul Hernandez, Robert E Roses, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, United States.

World Journal of Gastroenterology
|March 23, 2016
PubMed

Insights

Nonfunctional pancreatic neuroendocrine tumors (NF-PNETs) are common and often metastatic. Multidisciplinary treatment, including surgery, can improve survival for patients with advanced NF-PNETs.

Area of Science:

  • Oncology
  • Endocrinology

Background:

  • Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms.
  • Nonfunctional PNETs (NF-PNETs) represent the majority of PNET cases.
  • Many patients present with metastatic disease.

Observation:

  • Treatment options for PNETs include medical, liver-directed, and surgical approaches.
  • Aggressive surgical management may prolong survival in NF-PNET patients.
  • Data on surgical outcomes are limited by selection bias and co-occurring carcinoid tumors.

Findings:

  • While cure is rare in metastatic PNETs, current therapies can yield positive results.
  • A multidisciplinary approach is crucial for managing NF-PNETs.
  • Prolonged patient survival is achievable with comprehensive treatment strategies.

Implications:

  • Optimizing treatment strategies for NF-PNETs is essential for improving patient outcomes.
  • Further research is needed to overcome data limitations and refine surgical indications.
  • Multidisciplinary care models can enhance survival for patients with advanced pancreatic neuroendocrine tumors.
Keywords:
MultidisciplinaryNeuroendocrine tumorNonfunctionalPancreasPancreatic neuroendocrine tumor

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